α1-antitrypsin and survival in hepatocellular carcinoma

Alpha-1-antitrypsin deficiency and hepatocellular carcinoma.

Forty-two cases of hepatocellular carcinoma (HCC) were examined for the presence of the inclusions of alpha-1-antitrypsin (AAT), which indicate a carrier state for the Pi Z gene. These were found in the non-neoplastic liver tissue of two cases of HCC and in one of the 98 control livers, a difference that is not statistically significant. Typical globules of AAT deficiency were not found in HCC ...

Alpha-i -antitrypsin deficiency and hepatocellular carcinoma

It has been established that alpha-1-antitrypsin (AAT) deficiency due to the homozygous Pi Z state may give rise to cirrhosis and hepatic fibrosis, although the mechanism whereby this occurs is obscure. Also there are numerous reports of hepatocellular carcinoma (HCC) developing in such cases (Ganrot et al., 1967; Berg and Eriksson, 1972; Eriksson and Hagerstrand, 1974). The position of the het...

alpha-۱-antitrypsin in pathogenesis of hepatocellular carcinoma

context alpha-1-antitrypsin (a1at) is the most abundant liver-derived, highly polymorphic, glycoprotein in plasma. hereditary deficiency of alpha-1-antitrypsin in plasma (a1atd) is a consequence of accumulation of polymers of a1at mutants in endoplasmic reticulum of hepatocytes and other a1at-producing cells. one of the clinical manifestations of a1atd is liver disease in childhood and cirrhosi...

Hepatocellular Carcinoma in Sheep

α1-Antitrypsin deficiency: count me in please!

Respiratory medicine is facing formidable challenges in the 21st century. Indeed, most respiratory medical research is becoming interconnected, translational and transnational, all embedded within so-called “planetary health” [1]. However, renewing estimates and trends from classical, descriptive epidemiology, including how many patients of a given condition are around, and how many are expecte...